NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award
The NIH SBIR Phase IIB Strategic Breakthrough Award provides late-stage funding for highly innovative, high-impact biomedical or behavioral research projects that have completed Phase II funding and are transitioning toward commercialization.
Deadline
April 6, 2029
Est. Time
3-6 months
Source
SBA Funding Programs
Eligibility Requirements
Applicants must be U.S.-based for-profit small business concerns with fewer than 500 employees, possessing the research capabilities to perform the proposed biomedical work.
Who Can Apply
Small business concerns meeting NIH SBIR eligibility requirements, specifically those with a previously successful Phase II project.
Application Instructions
Applicants must register with SAM.gov, Grants.gov, and the eRA Commons before applying through the NIH application portal.
Required Documents
- Research Plan
- Budget Justification
- Commercialization Plan
- Biosketches
- Facilities and Other Resources
- Letter of Intent (if required)
Geographic Restrictions
United States
Required Essays
- Specific Aims
- Research Strategy
- Commercialization Plan
How to Stand Out
Demonstrate a clear pathway to commercialization, provide robust preliminary data from the initial Phase II project, and show strong potential for significant public health impact.
Risk Warnings
This is a highly competitive federal grant. Ensure strict compliance with all NIH administrative and reporting guidelines to avoid disqualification.