NIH Small Business Innovation Research (SBIR) Grant (Parent R43/R44) Clinical Trial Optional
The NIH Small Business Innovation Research (SBIR) program provides non-dilutive funding to small businesses for research and development projects with strong potential for commercialization in the biomedical and behavioral health sectors.
Deadline
Rolling
Est. Time
3-6 months for proposal development
Source
SBIR/STTR
Eligibility Requirements
Must be a US-based, for-profit small business with 500 or fewer employees. The principal investigator must have their primary employment with the small business at the time of award.
Who Can Apply
Small businesses, startups, and innovation-focused entities in the US.
Application Instructions
Applicants must register with SAM.gov, Grants.gov, and the NIH eRA Commons before submitting via the SF424 application package provided on the NIH funding opportunity announcement page.
Required Documents
- SF424 Application Package
- Research Strategy
- Budget Justification
- Commercialization Plan
- SBIR/STTR Information Form
Geographic Restrictions
United States
Required Essays
- Specific Aims
- Research Strategy
- Commercialization Plan
How to Stand Out
Focus heavily on the commercialization potential and clear, measurable milestones. Align the project goals with NIH mission priorities and ensure the technical team is well-qualified.
Risk Warnings
Federal grants are highly competitive and require strict compliance with administrative and reporting requirements. Failure to maintain registration or follow NIH guidelines can lead to immediate disqualification.